The Union Pacific and the Central Pacific tracks were laid in the bend of the Medicine River. As a result of the two railroads the town of Medicine Bow arose. The river supplied a tank at the railroad that was kept for the engines. Soon after a general store, two saloons, and a hotel were built. The Hotel Virginian was an inspiration for the writer Owen Wister.
Wind energy development is what Medicine Bow is famous for. There is much to do in this small town. Hunting, fishing, camping, hiking and historical research are a few options to choose from here in Medicine Bow.